Durante un soggiorno a Berlino, la quindicenne Juni incontra Sahal, coetaneo somalo fuggito dal suo paese, che vive nascosto in un cimitero. Juni non conosce il suo trascorso, ma č chiaro che ha bisogno di aiuto... Una storia di amicizia profondamente attuale che affronta attraverso gli occhi di due ragazzi il dramma dell'immigrazione e fa riflettere sui nostri comportamenti. Fino a dove deve arrivare il senso di responsabilitą verso un'altra persona? Qual č il confine tra giustizia e illegalitą? Ed č bene fidarsi di qualcuno che conosciamo appena? Etą di lettura: da 13 anni.

Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success. This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.

La vera tendenza del momento? Orologi che sono in realtą veri e propri gioielli. In questo volume vi mostreremo come creare bracciali, collane, spille o portachiavi, combinando orologi acquistati presso rivenditori specializzati con scintillanti perline Swarovski, di vetro, di cera o rocailles.