Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy
Book (italiano):
This text contains a selection of papers that were presented at an international symposium in Verona, Italy in December 2007, focusing on recent research on platinum coordination compounds in cancer chemotherapy. An opening overview is followed by 41 contributions by 147 international researchers organized into four sections covering novel platinum analogues, original formulations and other heavy metals; cellular transport and intracellular trafficking of platinum compounds; DNA damage and signal transduction--recognition/repair and cell- response; and clinical applications. A sampling of topics; nanocapsules of platinum-based anticancer drugs, resistance to cisplain results from multiple mechanisms in cancer cells, differences in conformation and conformational dynamics between cisplatin and oxaliplatin DNA adducts, platinum compounds in lung cancer, oxaliplatin-based chemotherapy for colon cancer, platins in newly- diagnosed endometrial cancer, intraperitoneal chemotherapy in ovarian cancer treatment, organic cation transporters 2 as mediators of cisplatin nephrotoxicity, and platinum drugs in children with cancer. Annotation ©2009 Book News, Inc., Portland, OR (booknews.com)
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