Ecco Topino! Vive insieme al suo migliore amico Gufo Reale, insieme si divertono sempre moltissimo: giocano a nascondino, fanno i pigiama party... ma Gufo Reale sembra molto impegnato a nutrire Topino di ciambelle, e poi è sempre lì. Topino non può proprio scappare... infatti ecco che si ritrova incastrato al buio! Gufo Reale sarà pronto a salvarlo? Età di lettura: da 3 anni.

C'era una volta un bosco. E tre volpi. Tre volpi affamate a caccia di conigli. Ma la caccia ai conigli non è sempre così semplice... Età di lettura: da 3 anni.

C'era una volta una caverna. E un lupo. E una piccola creatura che non usciva mai dalla caverna a causa del lupo. Età di lettura: da 3 anni.

When Mary Lennox is sent from India to the moors of England to live with her uncle after losing her parents, not only does she discover a secret garden, but she also discovers the true meaning of family, friendship, and perseverence. This magical, timeless classic, originally published in 1911, is by the author of A Little Princess and Little Lord Faunteleroy. This collectible edition, packaged in a beautiful, vibrant clothbound hardcover, is unabridged and includes 8 color illustrations by Charles Robinson.

'It was the sweetest, most mysterious-looking place any one could imagine.'

When spoiled, rude Mary Lennox is sent to live in her uncle's lonely house on the moors, she is miserable and alone. Then one day she discovers the key to a locked garden, and she discovers the beauty that life can offer. The Heritage edition of this best-loved tale features the gorgeous 1911 color illustrations by renowned illustrator Charles Robinson.

Young orphan Mary Lennox is sent to live with her uncle on the gloomy English moors. There, with the help of a secret garden, she enters a world she could never have imagined.

The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated third edition carries on the book's tradition of serving as the definitive reference on pesticide toxicology and recognizies the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition.

Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work.
Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles.


Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions
Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment.


Feature: All major classes of pesticide considered.
Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts.


Feature: Different routes of exposure critically evaluated.
Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.

An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals

Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition.

Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include:

• New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics
• Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters
• Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity

Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.

Ten-year-old Mary comes to live in a lonely house on the Yorkshire moors and discovers an invalid cousin and the mysteries of a locked garden.