Jesse Custer, joined by his girlfriend, Tulip, continues in his search to find God and hold Him accountable for His actions, but first he must manage to survive his ex-friend, Cassidy, as well as Starr, the deranged leader of the Grail conspiracy.

Jesse Custer is on the trail of his gun-toting girlfriend, Tulip, who believes that he's dead. And when Jesse finally catches up with Tulip, she tells him the truth about his supposed friend, Cassidy, leading up to a brutal confrontation between Custer and Cassidy.

Follows preacher Jesse Custer's journey across America in search of God, who abandoned Heaven when Genesis, the product of an angel and a demon, was born.